Enhanced expression of a biosimilar monoclonal antibody with a novel NS0 platform

Darryl Sampey, Pascal Courville, David Acree, Jeffrey Hausfeld and William E. Bentley. Biotechnology Progress. January 2018.

The precise product quality and lower cost of goods demands of the growing biosimilars industry are driving biomanufacturing innovation. Biosimilar cell lines that produce complex glycoproteins such as monoclonal antibodies must be both highly productive and express a product with critical quality attributes closely matching those of the innovator reference. In this work, a biomanufacturing platform is described that harnesses the commercially-established NS0 host cell in new ways to create stable, highly productive cell lines…