BioFactura Contract Services
Biopharmaceutical Development and Manufacturing
BioFactura’s biopharmaceutical industry experience is grounded in bioprocess development, scale-up, and manufacturing. The Company has capabilities to develop a broad range of upstream bioprocesses in bacterial, yeast, and mammalian cell culture expression systems. This includes the development of expression vectors and cell lines through medium optimization and process scale-up. BioFactura is also highly experienced in developing downstream recovery and purification processes. Steps may include centrifugation, depth and micro/ultra-filtration, and chromatography (affinity, ion-exchange, gel filtration). The Company is also well versed in developing and performing in-process and release analytical assays including various HPLC methods, SDS-PAGE and Western analysis, antibody/antigen capture ELISAs, purity assays (endotoxin, HCP, residual protein A), and bioactivity methods such as viral neutralization (BSL-2).